Kinetic constants for mutant and wild type PNPs from P. falciparum and T. gondii.

The mean (±) SD is calculated under the reaction conditions as described in the Materials and Methods section.(-) Activity not detected under the experimental conditions.a Residues that surround the 5′-hydroxyl group of Immucillin H [17].b Residues from active site that are from adjacent subunit [17], [20].c Residues that surround the 5′-methylthio group of MT-Immucillin H [17].