Preterm children are at increased risk of insulin resistance, obesity, and cardiovascular disease. We hypothesise that adverse early life events in preterm children may lead to alterations in the gut
BackgroundMacrophage-derived factors contribute to whole-body insulin resistance, partly by impinging on metabolically active tissues. As proof of principle for this interaction, conditioned medium fr
Data are mean ± SD, median (minimum - maximum values) or %. BMI, body mass index; HOMA-IR, homeostasis model assessment - insulin resistance; Met, metformin; SU, sulfonylureas.aData were analyzed usin
To investigate the mechanisms of lipid-activated protein kinase C (PKC) family, PKCδ or PKCɛ, involved in insulin resistance and fatty acid metabolism, we employed an in vivo adaptation of SILAC to ex
Purpose: To reveal the mechanism of mitochondrial DNA methylation in the progression of fatty liver and insulin resistance. Methods: Liver mitochondrial DNA bisulfite-sequencing of high-fat diet (HFD)
