Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors
收藏NIAID Data Ecosystem2026-03-14 收录
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资源简介：
We investigated the skeletal effects of conditional overexpression of Runx1 in preosteoclasts by crossing novel Runx1 gain-of-function mice (Rosa26-LSL-Runx1) with LysM-Cre transgenic mice. Overall design: The global expression profile duirng osteclast differentiation at day 3 and 5 was compared between Rosa26-Runx1tg/+ cells (control mice) and LysM-Cre;Rosa26-Runx1tg/+ cells (Runx1 gain-of-function) to determine the effects of Runx1 upregulation on osteoclast formation
创建时间：
2023-01-25
