Identification of genome editing nucleases off-target activity

NIAID Data Ecosystem2026-03-11 收录

基因编辑脱靶检测

下一代测序技术

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA609560 数据链接链接失效反馈

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ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing

创建时间：

2020-03-01

Supporting data for "Hi-C chromosome conformation capture sequencing of avian genomes using the BGISEQ-500 platform"

基因组学

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Hi-C experiments couple DNA-DNA proximity with next-generation sequencing to yield an unbiased description of genome-wide interactions. Previous methods describing Hi-C experiments have focused on the

Mendeley Data2024-01-31 更新100

Synthetic errors in chemical synthesis of oligonucleotide

寡核苷酸合成

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Synthetic errors derived from chemically synthesized oligonucleotide is a critical factor that limits the length and cost of synthesized genes and genomes. To improve the quality of synthesized oligon

NIAID Data Ecosystem80

Case report: Next Generation Sequencing in clinical practice – a real tool for ending the protracted diagnostic odyssey. NGS for diagnosing rare disorders

罕见病基因诊断

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We report a case of sitosterolemia, which is a rare genetic disease, characterized by increased plant sterol absorption and great heterogeneity of clinical manifestations. Our patient was initially re

NIAID Data Ecosystem50

Full-length sequencing of a heterogeneous five HIV-1 virus mixture. Human immunodeficiency virus 1

HIV-1基因组

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Here we provide data sets based on the mixture of five HIV-1 strains (HXB2, NL4-3, 89.6, JR-CSF, YU2) using three of the most common NGS platforms (454/Roche, Illumina, PacBio).

NIAID Data Ecosystem90

Additional file 5: Table S3. of Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

突变体分析

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Detailed information of all somatic mutations in targeted amplicon sequencing (TAS), including coverage, VAF and estimated contamination level. (XLSX 20 kb)

DataCite Commons2024-12-16 更新60

Identification of genome editing nucleases off-target activity

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