Tandem Construction of Indole-Fused Phthalazines from (2-Alkynylbenzylidene)hydrazines under Metal-Free Conditions
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An efficient approach to invent diversely substituted indole-fused phthalazines from in situ formed (2-alkynylbenzylidene)hydrazines under metal-free conditions via selective radical cyclization has been developed. Notably, this 6-exo-dig addition–cyclization tandem procedure proceeds under air atmosphere and shows a broad substrate suitability, as well as avoids harmful byproducts, which complies with the concept of green synthesis.
创建时间:
2020-02-07



