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Single CRISPR base editors to induce simultaneous C-to-T and A-to-G mutations

NIAID Data Ecosystem2026-03-13 收录

CRISPR碱基编辑

基因突变诱导

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP238172 数据链接链接失效反馈

官方服务：

资源简介：

High-throughput sequencing data of CRISPR base editing assays in human cells

应用场景：

创建时间：

2022-01-12

人类基因组编辑

CRISPR碱基编辑

Recently, base editors, composed of cytidine deaminase, Cas9 nickase (nCas9), and uracil DNA glycosylase inhibitor (UGI), have recently been developed to substitute a C at a target site with T without

NIAID Data Ecosystem70

Table_1_Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti.DOCX

CRISPR碱基编辑

根瘤菌基因组操作

Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature. Although

NIAID Data Ecosystem30

The CRISPR-based C-to-T base editing system

CRISPR碱基编辑

斑马鱼基因组

The codon-optimized zAncBE4max construct contains the Uracil glycosylase inhibitor(UGI) and Deaminase (rAPOBEC1)-coupled Cas9a D10A nicknase, and NLS to enabe C-to-T base editing in the whole genome o

NIAID Data Ecosystem30

Highly efficient CRISPR-mediated base editing for the gut Bacteroides spp. with pnCasBS-CBE

肠道菌群基因编辑

CRISPR碱基编辑

We constructed a pnCasBS-CBE system for base editing in the Bacteroides thetaiotaomicron to expand their genetic toolkit, which can efficiently convert a C:G to a T:A in the genome. As a functional pr

NIAID Data Ecosystem40

Single CRISPR base editors to induce simultaneous C-to-T and A-to-G mutations

CRISPR碱基编辑

高通量测序

High-throughput sequencing data of CRISPR base editing assays in human cells

NIAID Data Ecosystem30