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Polyamide Efficacy in Enzalutamide-Resistant Prostate Cancer

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NIAID Data Ecosystem2026-03-10 收录
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We report the biological activity of a Py-Im polyamide targeted to the sequence 5'-WGWWCW-3', which is found in a subset of ARE half-sites. This molecule reduces the growth of enzalutamide-resistant LREX' cells, both in vitro and in vivo. Gene expression changes associated with polyamide treatment in both settings are deposited here.

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2017-03-30
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