Supplementary Video from Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-¹³C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

Animation of the dynamic conversion of hyperpolarized pyruvate into lactate in a murine model of anaplastic thyroid cancer. Heat maps for (left) HP pyruvate and (right) HP lactate overlay T2-weighted MRI. This animation can be estimated with arbitrary temporal resolution following model-based reconstruction from highly undersampled data.