Summary of the 24 replicated multiple sclerosis associated risk loci.

RAF: risk allele frequency, OR: odds ratio, 95% CI: 95% confidence interval.OR and p-value represent the combined discovery and replication study results [9]. Risk allele frequency refers to allele frequency in control population of UK samples. For CBLB is the discovery OR and p-value given.Reprinted by permission from Macmillan Publishers Ltd: The International Multiple Sclerosis Genetics Consortium and The Wellcome Trust Case Control Consortium. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 2011, Nature 476: 214–219.