Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors

NIAID Data Ecosystem2026-05-02 收录

β-内酰胺酶抑制剂

抗菌药物发现

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Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors

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2024-10-16

Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β‑Lactamase Inhibitors

绿色化学合成

β-内酰胺酶抑制剂

Herein, the amide coupling of six primary amines with the sodium salt of diazabicyclooctane acid in an aqueous medium without an additional base/surfactant or organic solvent is described. The product

Figshare60

Aminoglycoside–Peptide Nucleic Acid (PNA) conjugates against Gram-negative bacteria

抗菌药物发现

基因沉默疗法

Research data in the form of Tab-delimited text files: growth (OD600) of the bacterial strains (E. coli AS19, E. coli K12, E. coli WR 3551/98, E. coli K12 mutant lacking sbmA gene, E. coli ML-35 and S

DataCite Commons2026-03-04 更新50

Crystal structure of S. aureus FabI inhibited by SKTS1

抑制剂结构

抗菌药物发现

Crystal structure of S. aureus FabI inhibited by SKTS1 Descriptor: 6-[4-(4-hexyl-2-oxidanyl-phenoxy)phenoxy]pyridin-2-ol, Enoyl-[acyl-carrier-protein] reductase [NADPH], NADP NICOTINAMIDE-ADENINE-DINU

Protein Data Bank Japan2024-01-24 更新30

Structure of D179N BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam

结核分枝杆菌耐药酶结构

β-内酰胺酶抑制剂

Structure of D179N BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam Descriptor: Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... Authors: Chikunova, A, Bruenle, S, Ubbin

Protein Data Bank Japan2024-11-13 更新50

Novel bacterial methionine aminopeptidase inhibitors

抗菌药物发现

细菌酶抑制

Novel bacterial methionine aminopeptidase inhibitors

NIAID Data Ecosystem40