The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.
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The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114. Descriptor: 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM Authors: Berndt, A, Miller, S, Williams, O, Lee, D.D, Houseman, B.T, Pacold, J.I, Gorrec, F, Hon, W.-C, Liu, Y, Rommel, C, Gaillard, P, Ruckle, T, Schwarz, M.K, Shokat, K.M, Shaw, J.P, Williams, R.L. Deposit date: 2010-01-22 Release date: 2010-02-02 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors Nat.Chem.Biol., 6, 2010
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2010-01-22
