Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes a deterioration in beta cell functio
C. elegans DAF-16/FOXO phosphorylation in different genetic backgrounds was analyzed by mass spectrometry of affinity purified HA-tagged DAF-16. Genetic backgrounds studied include par-1 hypomorphic m
Animals were scored for presence of nuclear puncta after treatment with DMSO, daf-2(RNAi), FLA or following a 2 hour heat-shock incubation at 37°C. A Student's T-Test was used to determine statistical
The liver is the central organ for carbohydrate metabolism to maintain the blood glucose concentration within a normal range. Glucose breakdown or synthesis in the liver is tightly regulated by insuli
