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Promoter- and Enhancer-Dependent Cohesin Loading Initiates Chromosome Looping to Fold Tcrb Loci for Long-Range Recombination

NIAID Data Ecosystem2026-05-10 收录

染色体构象调控

V(D)J重组

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296315 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-09-22

V(D)J重组

淋巴细胞受体基因重组

A central unanswered question concerning the initial phases of V(D)J recombination has been at which step the 12/23 rule applies. This rule, which governs which variable (V), diversity (D), and joinin

PubMed Central70

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination (3C-HTGTS)

V(D)J重组

染色质构象

Immunoglobulin heavy chain locus (Igh) VH, D, and JH gene segments are developmentally assembled into V(D)J exons. RAG endonuclease initiates V(D)J recombination by binding a JH-recombination signal s

NIAID Data Ecosystem50

Allele-specific H3K27me3, H3K27ac and Ctcf ChIP-seq in Smchd1 control and Smchd1 deleted female neural stem cells. [H3K27me3]

染色体构象调控

神经细胞表观遗传学

We sought to examine whether the non-canonical SMC protein Smchd1 plays a role in chromosome conformation. We used in situ Hi-C to analyse chromosome conformation changes upon deletion of the epigenet

NIAID Data Ecosystem40

Structure of full-length SMC and rearrangements required for chromosome organization

染色体构象调控

SMC蛋白功能

In vitro biochemical assay, high throughput crosslinking screen, chromatin immunoprecipitation

NIAID Data Ecosystem60

NUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome

先天性免疫缺陷疾病

V(D)J重组

Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detec

NIAID Data Ecosystem40

Promoter- and Enhancer-Dependent Cohesin Loading Initiates Chromosome Looping to Fold Tcrb Loci for Long-Range Recombination

资源简介：

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