Inhibition of uPA expression by CRISPR-dCas9 DNA methyltransferases

ChEBI2016-06-01 更新2026-07-12 收录

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疾病靶点调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74935 数据链接链接失效反馈

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Inhibition of uPA expression by CRISPR-dCas9 DNA methyltransferases

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2016-06-01

Bioorthogonal Chemical Epigenetic Modifiers Enable Dose-Dependent CRISPR Targeted Gene Activation in Mammalian Cells

基因调控

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CRISPR-Cas9 systems have been developed to regulate gene expression by using either fusions to epigenetic regulators or, more recently, through the use of chemically mediated strategies. These approac

NIAID Data Ecosystem80

Whole-genome DNA methylation maps for human and chimpanzee peripheral blood leukocytes (PBLs).

跨物种DNA甲基化分析

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It has been thought that epigenetic changes underlie the evolutionary divergence of phenotype between closely related species. To study differences in DNA methylation between humans and chimanzees, we

NIAID Data Ecosystem50

Epigenetic regulation of iTreg cell differentiation by Nr4a family of transcription factors

细胞分化调控

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Helper T (Th) and regulatory T (Treg) cell differentiation programs promote the eradication of pathogens, while minimizing adverse immune reactions. In this study, we investigated the roles of Nr4a fa

NIAID Data Ecosystem40

8p H3K27me3 Part 2

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X染色体失活

Green is RNA FISH using a probe against XIST RNA. Red is an anti-H3K27me3 antibody. Blue is DAPI. These images were used to calculate data shown in Table 2.

Figshare2016-01-20 更新80

Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.

转录调控

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The conserved core domain of the TATA binding protein (TBP) interacts with multiple partners forming the complexes required for transcription by RNA Polymerases I, II and III. We use genetically modif

NIAID Data Ecosystem50

Inhibition of uPA expression by CRISPR-dCas9 DNA methyltransferases

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