Synthesis of 1,2,4-Trisubstituted-(1<i>H</i>)‑imidazoles through Cu(OTf)<sub>2</sub>‑/I<sub>2</sub>‑Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines
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1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu(OTf)2- and I2-catalyzed unusual C–C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C–C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroaryl-substituted chalcones and benzylamines were well tolerated in this unusual transformation to yield the trisubstituted-(1H)-imidazoles.
创建时间：
2018-07-19
