Transcription profiling of liver from wild type mice of different ages to determine whether gene expression changes in naturally aged mice overlap with those from DNA repair deficient mice

To investigate whether and to which extent the gene expression changes in DNA repair deficient mice (i.e. Csbm/m/Xpa-/- and Ercc1-/-) overlap with those observed in a natural aged liver, we sought to compare the full mouse liver transcriptome of adult 16-, 96- and 130-week old wt C57Bl/6J mice (n=4) with that of adult 8-week old wt C57Bl/6J mice为探究DNA修复缺陷型小鼠（即Csbm/m/Xpa-/-与Ercc1-/-品系）的基因表达变化与自然衰老肝脏中观测到的基因表达变化是否存在重叠及重叠程度，本研究拟比较16周龄、96周龄及130周龄成年野生型（wild type, wt）C57Bl/6J小鼠（每组n=4）与8周龄成年野生型C57Bl/6J小鼠的小鼠全肝转录组。