Crystal structure of GMPPNP bound KRAS G12C in complex with CYPA and RMC-7977

Crystal structure of GMPPNP bound KRAS G12C in complex with CYPA and RMC-7977 Descriptor: (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... Authors: Pourfarjam, Y, Goldgur, Y, Cuevas-Navarro, A, Lito, P. Deposit date: 2024-04-22 Release date: 2024-11-06 Last modified: 2025-01-29 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Pharmacological restoration of GTP hydrolysis by mutant RAS. Nature, 637, 2025