Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes

To investigate the effect of glucose hypometabolism on the transcriptome of human neurons Overall design: Comparative gene expression analysis of RNAseq data for human i3Neurons treated with either complete/normal media, glucose-deprived media, or 2-deoxyglucose-containing media. Two independent differentiations for two different i3Neurons lines (for a total n = 4) were used for each condition