Immunogenicity of the pan-DENV sequences in HLA-DR transgenic mice.

aAssessed by IFN-γ ELISpot assay in HLA-DR2 (DRB1*1501), HLA-DR3 (DRB1*0301) and HLA-DR4 (DRB1*0401) Tg mice immunized with DENV-3 peptides (see Methods) bAmino acid positions numbered according to the sequence alignments of the 4 DENV types cSequences present in the pan-DENV sequences are underlined dSFC, spot-forming cells; SD, standard deviation. Representative results from at least two immunized Tg mice are shown, except when indicated by an asterisk