Table S1 from Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors
收藏NIAID Data Ecosystem2026-05-17 收录
数据链接:
官方服务:
资源简介:
Nuclear proteins
应用场景:
创建时间:
2017-10-15
相关数据集
Tandem duplications in UBTF create XPO1-dependent nuclear export signals necessary for leukemic progression [scRNA-seq]
UBTF tandem duplications (UBTF-TD) define a high-risk molecular subtype of acute myeloid leukemia (AML) characterized by poor clinical outcomes. While menin inhibitors have shown therapeutic promise,
NIAID Data Ecosystem40
XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor KPT-335.. XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor KPT-335.
The five-year survival rate remains less than 50% for high-risk neuroblastoma patients, few of them show effective response to current chemotherapy drugs. It is urgent to identify new therapeutic targ
NIAID Data Ecosystem20
Selinexor, a First-in-Class XPO1 Inhibitor, Is Efficacious and Tolerable in Patients with Myelodysplastic Syndromes Refractory to Hypomethylating Agents
PURPOSE The median overall survival (OS) of patients with high-risk myelodysplastic syndromes (MDS) refractory to hypomethylating agents is less than 6 months and there is no standard therapy for suc
NIAID Data Ecosystem10
Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1
Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 Descriptor: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ...
Protein Data Bank Japan2023-09-27 更新30
Prolonged XPO1 inhibition is essential to achieve optimal antileukemic activity in NPM1-mutated acute myeloid leukemia. Prolonged XPO1 inhibition is essential to achieve optimal antileukemic activity in NPM1-mutated acute myeloid leukemia
NPM1-mutated acute myeloid leukemia (AML) accounts for one third of AML in adults. NPM1-mutated AML maintenance depends on the interaction between mutated NPM1 (NPM1c) and the nuclear exporter Exporti
NIAID Data Ecosystem20



