首页/数据集/MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis

MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis

NIAID Data Ecosystem2026-05-02 收录

淋巴瘤发生机制

MEF2B突变功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE234684 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-09-30

淋巴瘤发生机制

转录因子调控网络

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic lesions have been discovered and their functi

NIAID Data Ecosystem100

Pre-neoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma [scRNA-seq]

淋巴瘤发生机制

肿瘤前体突变

Normal-cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B-lymphocytes prior to lymphoma remains uncertain. We sequenced multiple st

NIAID Data Ecosystem70

The class-specific BCR tonic signal modulates lymphomagenesis in a transgenic model of c-myc transgene deregulation.

淋巴瘤发生机制

肿瘤免疫表型调控

c-myc-3'RR mice developed Burkitt like lymphoma (IgM and IgD positive cells). We wished to study lymphomagenesis in mice carrying a modified B cell receptor with a higher level of tonic signal. The c-

NIAID Data Ecosystem20

Unrestricted SUMOylation drives lymphomagenesis

SUMOylation修饰

淋巴瘤发生机制

Unrestricted SUMOylation drives lymphomagenesis Overall design: Unrestricted SUMOylation drives lymphomagenesis

NIAID Data Ecosystem90

Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation (HiC)

细胞分化调控

淋巴瘤发生机制

During the germinal center (GC) reaction, B-cells undergo extensive redistribution of cohesin complex and 3D re-organization of their genomes. Yet, the significance of cohesin and architectural progra

NIAID Data Ecosystem20

MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis

资源简介：

相关数据集