TIGER

Here, we present TIGER, a tumor immunotherapy gene expression resource, which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor/normal samples without clinical immunotherapy outcomes, as well as single-cell transcriptome data of 2,116,945 immune cells from 655 samples. TIGER provides many useful modules for analyzing collected and user-provided data. Using the resource in TIGER, we identified a tumor-enriched subset of CD4+ T cells. Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy.本研究发布了TIGER（肿瘤免疫治疗基因表达资源，tumor immunotherapy gene expression resource），该资源包含1,508例携带临床免疫治疗结局的肿瘤样本的批量转录组数据、11,057例无临床免疫治疗结局的肿瘤/正常样本的批量转录组数据，以及来自655份样本的2,116,945个免疫细胞的单细胞转录组数据。TIGER提供了多种实用分析模块，可用于处理已收录数据及用户自主提交的数据。依托该资源，本研究鉴定出一类肿瘤富集的CD4+ T细胞亚群；该亚群特征评分更高的黑色素瘤患者，在接受免疫治疗时可获得更显著的治疗应答与更长的生存获益。

搜集汇总

背景与挑战

背景概述

TIGER是一个肿瘤免疫治疗基因表达资源网络门户，整合了批量转录组数据和单细胞转录组数据，包括1508个有免疫治疗临床结果的肿瘤样本和超过211万个免疫细胞。该资源提供多个分析模块，如单细胞免疫和免疫治疗响应，用于支持肿瘤免疫学的基因表达分析。