Differentially expressed mRNAs in lungs between hypoxic human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (Hypo-EVs)-INH-treated mice and OVA-induced asthma mice

To better understand the molecular processes of nebulized Hypo-Evs on asthma intervention, OVA-induced chronic asthma model were established (OVA group), and a therapeutic regimen was instigated by inhaling Hypo-EVs four times (Hypo-EVs group) . Then a global RNA sequencing of mouse lung from the OVA and Hypo-EVs groups was performed. Overall design: Comparative gene expression profiling analysis of mouse lung from the OVA and Hypo-EVs groups.