Enantioselective Catalytic α-Alkylation of Aldehydes via an S<sub>N</sub>1 Pathway
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Primary aminothiourea derivatives are shown to catalyze enantioselective alkylation of α-arylpriopionaldehdyes with diarylbromomethane. Evidence for a stepwise, SN1 mechanism in the substitution reaction induced by anion binding to the catalyst is provided by catalyst structure−activity studies, kinetic isotope effects, linear free-energy relationship studies, and competition experiments.
创建时间：
2010-07-14
