Replication Study Results and Combined Meta-Analysis.

Combined association results for 12 SNPs representing 5 independent regions that reached genome-wide significance in the original GWAS. The combined effect estimates (per allele odds ratios) in the replication cohorts were all direction-consistent with the ones in the original GWAS cohorts. Significant heterogeneity was noted only for the second HLA locus represented by rs9357155 and rs2071543. Q-test: P-value for the Cochrane's Q statistic for heterogeneity, NS: heterogeneity test not significant, *heterogeneity P<0.05, **heterogeneity P<0.01; I2: Heterogeneity Index (0–100%), where <25% corresponds to low, 50%–75% to medium, and >75% to high level of heterogeneity; OR: Additive (per-allele) Odds Ratio; #Han and Eskin random effects model.