PD-1-PD-L1 Axis Activation Suppresses CD8+ T Cells and Improves Nephritis [RNA-seq]

PD-1+CD8+ T cells are exhausted in infection and cancer, their roles in lupus nephritis (LN) are largely unknown. PD-1+CD8+ and PD-1-CD8+ cells from spleens of NZB/W F1 mice were sorted for RNA-seq. Comparative gene expression profiling analysis of RNA-seq data for PD-1+CD8+ and PD-1-CD8+ cells from spleens of NZB/W F1 mice.PD-1+CD8+ T细胞在感染与癌症中处于耗竭状态，其在狼疮肾炎（lupus nephritis, LN）中的作用尚不清楚。研究人员从NZB/W F1小鼠的脾脏中分选得到PD-1+CD8+与PD-1-CD8+ T细胞，进行RNA测序（RNA-seq），并针对该两类细胞的RNA测序数据开展比较基因表达谱分析。