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Single Cell and Tissue Level Functional Genomics Analysis of Astrocyte-Related Mechanisms in Taupathy

NIAID Data Ecosystem2026-04-25 收录

tau蛋白病变

星形胶质细胞功能基因组学

数据链接：

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002197.v1.p1 数据链接链接失效反馈

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资源简介：

This is the first data release for this study.]]>

应用场景：

创建时间：

2020-08-14

tau蛋白病变

表观遗传调控

In this dataset, we evalute the effect of modulating the levels of LSD1 in the PS19 tauopathy mouse (mouse that expresses the P301S mutated form of the human tau transgene). First we reduced the level

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Analysis of human tau and age dependent changes in the synaptic and non-synaptic mitochondrial proteomes of the htau model of tauopathy

tau蛋白病变

线粒体蛋白质组学

We investigated the effects of human tau on subcellular populations of the brain mitochondrial proteome in vivo using transgenic htau mice at ages preceding (5 months) and coinciding with (8 months) o

NIAID Data Ecosystem30

Single cell transcriptomic profiling of tau pathophysiology in a novel 3D neural-glial coculture model II. Single cell transcriptomic profiling of tau pathophysiology in a novel 3D neural-glial coculture model II

tau蛋白病变

单细胞转录组学

We report the development of a novel 3D human induced pluipotent stem cell derived neural-glial coculture model of tauopathy and identify pathways associated with pathogenesis by 10X 3' single cell RN

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Additional file 2 of Tau protein profiling in tauopathies: a human brain study

tau蛋白病变

人脑蛋白质组学

Supplementary Material 2: Figure 11

Figshare2024-08-18 更新50

tau蛋白病变

神经退行性疾病基因

Wildtype mice at either 3 or 12 months old were subjected to intrahippocampal injection with sarkosyl insoluble brain extracts from either human control or Alzheimer's disease brain. Mice were incubat

NIAID Data Ecosystem30

Single Cell and Tissue Level Functional Genomics Analysis of Astrocyte-Related Mechanisms in Taupathy

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