Transannular <i>O</i>‑Heterocyclization: A Useful Tool for the Total Synthesis of Murisolin and 16,19-<i>cis</i>-Murisolin
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Transannular O-heterocyclization is applied as a key step in a total synthesis. This highly stereoselective and metal-free transformation introduces four stereocenters in one step. It was chosen to be the pivotal step in the synthesis of Murisolin and 16,19-cis-Murisolin, two annonaceous acetogenins. The efficiency of this synthesis is further illustrated by a stereodivergent late-stage separation of both synthetic routes.
创建时间：
2012-11-16
