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Differentiation of XCR1- cDC1 into XCR1+ cDC1

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NIAID Data Ecosystem2026-05-01 收录
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In order to analyze whether XCR1- cDC1 represent immediate precursor of XCR1+ cDC1 and acquire functional abilities of XCR1+ cDC1, XCR1- and XCR1+ cDC1 were cultured in a DC differentiation assay. Conclusion: XCR1- cDC1 acquire XCR1 expression on day 5 of the DC differentiation culture together with functional capacities of XCR1+ cDC1. Notes: Published in: Proceedings of the National Academy of Sciences (PNAS), 2023 Title: XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector function from their immediate precursors. Authors: Lukas Heger, Lukas Hatscher, Chunguang Liang, Christian H. K. Lehmann, Lukas Amon, Jennifer J. Lühr, Tomasz Kaszubowski, Rayk Nzirorera, Niels Schaft, Jan Dörrie, Pascal Irrgang, Matthias Tenbusch, Meik Kunz, Eileen Socher, Stella E. Autenrieth, Ariawan Purbojo, Horia Sirbu, Arndt Hartmann, Christoph Alexiou, Robert Cesnjevar, and Diana Dudziak doi: 10.1073/pnas.2300343120 Isotype controls 4°C controls
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2023-09-01
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