Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor

Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor Descriptor: HISTONE DEACETYLASE 4, N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide, POTASSIUM ION, ... Authors: Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A. Deposit date: 2008-03-17 Release date: 2008-07-08 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain. J.Biol.Chem., 283, 2008