Enantioselective Copper-Catalyzed Alkynylation of Benzopyranyl Oxocarbenium Ions
收藏NIAID Data Ecosystem2026-03-08 收录
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资源简介：
We have developed highly enantioselective, copper-catalyzed alkynylations of benzopyranyl acetals. By using a copper(I) catalyst equipped with a chiral bis(oxazoline) ligand, high yields and enantioselectivities are achieved in the alkynylation of widely available, racemic isochroman and chromene acetals to deliver α-chiral oxygen heterocycles. This method demonstrates that chiral organometallic nucleophiles can be successfully used in enantioselective additions to oxocarbenium ions.
创建时间：
2016-02-13
