Population data measurements from retrogradely labeled MG and SOL motoneurons.

Figshare2021-11-19 更新2026-04-28 收录

数据链接：

https://figshare.com/articles/dataset/Population_data_measurements_from_retrogradely_labeled_MG_and_SOL_motoneurons_/17051829 数据链接链接失效反馈

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资源简介：

Population data measurements from retrogradely labeled MG and SOL motoneurons.

创建时间：

2021-11-19

C9ORF72基因HRE敲入大鼠

基因敲入

运动神经元

HRE敲入大鼠体重和生殖能力正常，但与野生型大鼠相比，免疫器官有改变，脾脏无明显变化，胸腺显著减小，颈部淋巴结明显增大。外周血流式分析显示4月龄的HRE敲入大鼠中性粒细胞比例显著上升，淋巴细胞中CD3、CD4均显著降低。至12个月龄，未发现其他器官有明显缺陷。与WT相比KI大鼠12M时运动协调和肢体力量下降分别为68%和56%。雌性KI大鼠在13-24M年龄段后肢麻痹发生率为25%(5/20)。这

中国科技资源共享网2026-08-02 更新140

Implementation of the MiNDToolkit intervention for the management of behavioral symptoms in MND by healthcare professionals: a mixed-methods process evaluation

运动神经元

行为管理

MiNDToolkit is a novel psychoeducational intervention for carers to support management of behavioral symptoms in people living with motor neuron disease (PlwMND). Implementation of MiNDToolkit involve

DataCite Commons2024-07-24 更新60

Genetic and Functional Modularity of Hox Activities in the Specification of Limb-Innervating Motor Neurons

运动神经元

HOX基因功能

A critical step in the assembly of the neural circuits that control tetrapod locomotion is the specification of the lateral motor column (LMC), a diverse motor neuron population targeting limb muscula

Figshare2016-01-18 更新40

Dynamic enhancer landscape in postmitotic motor neurons

运动神经元

增强子动态

Generic spinal motor neuron identity is specified by cooperative binding of selector transcription factors to motor neuron specific enhancers. Whether these enhancers remain active to maintain the mot

NIAID Data Ecosystem60

RNA sequencing of MShef11 WT, MFN2R94Q/+, MFN2 R94Q/R94Q differentiated to limb innervating motor neurons. RNA sequencing of MShef11 WT, MFN2R94Q/+, MFN2 R94Q/R94Q differentiated to limb innervating motor neurons

CMT2A疾病模型

运动神经元

We have generated CRISPR edited versions of hESC line MShef11 to produce MFN2 R94Q/+ and MFN2 R94Q/R94Q lines as a model for Charcot Marie Tooth Disease (CMT) 2A. This were differentiated to limb inne

NIAID Data Ecosystem50

Population data measurements from retrogradely labeled MG and SOL motoneurons.

资源简介：

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