FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB

FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB Descriptor: (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, CALCIUM ION, ... Authors: Chung, C. Deposit date: 2021-08-19 Release date: 2021-09-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs. Angew.Chem.Int.Ed.Engl., 60, 2021