Diastereoselective Synthesis of the Leu-Pro Type Phosphinyl Dipeptide Isostere
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A diastereoselective synthesis of the Leu-Pro type phosphinyl dipeptide isostere in its protected form was achieved from stereodefined α-amino-H-phosphinate. The methodology involved a cross-coupling reaction with alkenyl triflate and subsequent diastereoselective hydrogenation of the alkene moiety, which capitalized on the phosphorus chirality.
创建时间：
2011-07-01
