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Wittig Olefination between Phosphine, Aldehyde, and Allylic Carbonate: A General Method for Stereoselective Synthesis of Trisubstituted 1,3-Dienes with Highly Variable Substituents

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A clean and salt-free Wittig olefination between phosphines, aldehydes, and allylic carbonates is described. It represents a general method for convenient and efficient synthesis of 1,2,4-trisubstituted 1,3-dienes from readily available starting materials. This method exhibits high synthetic efficiency, high stereoselectivity, and high variability of substituent.

创建时间:
2016-02-25
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