Synthesis of the Macrocyclic Core of (−)-Pladienolide B
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An efficient synthesis of the macrocyclic core of (−)-pladienolide B is disclosed. The concise route relies on a chiral auxiliary-mediated asymmetric aldol addition and an osmium-catalyzed asymmetric dihydroxylation to install the three oxygenated stereocenters of the macrocycle. This purely reagent-controlled and flexible strategy sets the stage for future analogue syntheses and structure−activity relationship plotting of the appealing anticancer lead structure pladienolide B.
创建时间：
2016-02-27
