Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, w

干细胞与再生医学数据中心2022-02-20 更新110

Epigenetic Memory Underlies Cell Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells

造血干细胞

表观遗传学

Stem cells determine homeostasis and repair of many tissues and are increasingly recognized as functionally heterogeneous. To define the extent of and molecular basis for heterogeneity we overlaid fun

干细胞与再生医学数据中心2022-02-20 更新100

PPARg marks splenic precursors of multiple nonlymphoid-tissue Treg compartments [scTCR-seq]

免疫学

细胞生物学

Foxp3+CD4+ regulatory T cells (Tregs) regulate most types of immune response as well as several processes important for tissue homeostasis â for example, metabolism and repair. Dedicated Treg compar

干细胞与再生医学数据中心2022-02-20 更新140

Mouse embryonic stem cells can differentiate via multiple paths to the same state [RNA-seq]

干细胞分化

RNA测序

In embryonic development, cells must differentiate through stereotypical sequences of intermediate states to generate mature states of a particular fate. By contrast, direct programming can generate s

干细胞与再生医学数据中心2022-02-20 更新110

Supporting data and code

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