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N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

NIAID Data Ecosystem2026-05-02 收录

mRNA翻译调控

RNA修饰功能

数据链接：

https://www.omicsdi.org/dataset/pride/PXD053919 数据链接链接失效反馈

官方服务：

资源简介：

Mass spectrometry on affinity-purified luciferase produced from constitutively modified or unmodified mRNA in HEK293 cells.

应用场景：

创建时间：

2025-05-07

果蝇生物学

mRNA翻译调控

The maternal mRNA nanos is required for anterior-posterior patterning in the early Drosophila melanogaster development. The nanos-mRNA is translationally repressed and deadenylated during the first tw

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A dual-activity topoisomerase complex regulates mRNA translation and turnover

mRNA翻译调控

mRNA周转

Topoisomerase 3β (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional

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Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Zhao, Ma, Ishiguro, et al.

RNA修饰功能

翻译效率调控

Source data for Figures 2B, 2D, 4E, 7C, and 7D, S2B, S24A.

NIAID Data Ecosystem20

Co-transcriptional pseudouridylation of mRNAs by the H/ACA complex controls translational efficiency [ChIP-seq]. Co-transcriptional pseudouridylation of mRNAs by the H/ACA complex controls translational efficiency [ChIP-seq]

mRNA翻译调控

假尿苷修饰机制

Post-transcriptional modifications of mRNA have emerged as novel regulators of gene expression. Pseudouridylation is the most abundant and widespread type of RNA modification in living organisms; howe

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Large-scale tethered function assays identify factors that regulate mRNA stability and translation (polysome profiling)

多聚核糖体图谱分析

mRNA翻译调控

Performed polysome profiling in cell lysates from two independent UBAP2L knockout clonal isolates and from two control samples. RNAseq

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