Botulinum toxin A enhances the rates of embryo implantation via elevation of endometrial angiogenesis

Intrauterine BoTA treatment has a beneficial effect on vascular reconstruction of functional endometrium prior to embryo implantation by increasing endometrial blood flow near the uterine cavity suggesting BoTA treatment as a potential therapeutic strategy for patients who are suffering from repeated implantation failure with the problems with endometrial receptivity. As a non-invasive treatment strategy, BoTA was infused into one side of mouse uterine horns and saline was infused into the other side of horns for the control (N=28). Assessment of BoTA impact on the endometrium at day3 and day8.