TNFAIP9 protects against the development of the early stage of chronic kidney disease: Focus on inflammation and fibrosis

Tumor necrosis factor alpha-induced protein 9 (TNFAIP9) is a crucial effector molecule that protects cells from inflammatory and metabolic damage. This study focuses on investigating the role and regulatory mechanisms of TNFAIP9 in the progression of chronic kidney disease (CKD). By analyzing CKD-related datasets from the GEO database, we discovered that TNFAIP9 was upregulated in CKD patients and CKD mice compared to their normal controls. To elucidate the functional role of TNFAIP9, we established a mouse model of CKD through a two-step 5/6 nephrectomy (Nx). The experimental mice were transduced with an adenoviral vector to express TNFAIP9. The results showed that mice undergoing 5/6-Nx developed evident renal impairment, inflammation, and fibrosis. Overexpression of TNFAIP9 resulted in the remission of renal impairment, a decreased inflammatory response, and a reduced expression of fibrotic markers. In vitro, human renal tubular epithelial human kidney-2 (HK-2) cells were exposed to ..., The current dataset provides raw data that can be used to form the histogram, including quantitative results of immunofluorescence/immunohistochemistry/pathology scores, kit results, and normalized quantitative results of PCR and Western blot., , # Data from: TNFAIP9 protects against the development of the early stage of chronic kidney disease: focus on inflammation and fibrosis **Introduction** This dataset includes raw data that can be used to form the histogram, including quantitative results of immunofluorescence/immunohistochemistry/pathology scores, kit results, and normalized quantitative results of PCR and Western blot to support the study “TNFAIP9 protects against the development of the early stage of chronic kidney disease: focus on inflammation and fibrosis”, which is currently in press. **File list** Original Data, in pptx format. **Author Information** Name: Ying Chen Institution: First Hospital of China Medical University, Shenyang, China Co-investigator 1 Name: Yanqiu Li Institution: First Hospital of China Medical University, Shenyang, China Corresponding author Name: Dr. Deyu Zhang Institution: Shengjing Hospital of China Medical University, Shenyang, China **Description of the data and file structure** The ...