Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential to design appropriate therapeutic strategies. In a recent study we reported an unexpec

NIAID Data Ecosystem50

Genomic instability induced by lowered expression of POL3 in yeast

DNA复制压力致癌机制

基因组不稳定性

DNA replication stress (DRS)-linked genomic instability has emerged as an important factor driving cancer development

Alliance of Genome Resources10

Hemizygous loss of helicases promotes genomic instability and cancer development

癌症基因组数据

基因组不稳定性

Cancer mutations perturb key processes, leading to uncontrolled cell proliferation. With the pivotal and specific roles for enzymes at all levels of cellular function and growth, we hypothesized that

DataONE2025-12-19 更新50

Genome-wide ChIP-chip Rad50 in early S-phase in the presence of hydroxyurea. Saccharomyces cerevisiae

DNA损伤修复

复制叉稳定性

The Mre11-Rad50-Xrs2 (MRX) complex is related to SMC complexes that form rings capable of holding two distinct DNA strands together. MRX functions at stalled replication forks and double-strand breaks

NIAID Data Ecosystem20

RADX prevents genome instability by confining replication fork reversal to stalled forks

资源简介：

相关数据集