Comparison of MSA with PD/DLB alpha-synuclein pathology using proximity proteomics

Multiple systems atrophy (MSA) is a unique synucleinopathy of unknown cause characterized by alpha-synuclein aggregates in oligodendroglia. Here, we used the in-situ proximity labeling technique biotinylation (BAR) by antibody recognition to identify alpha-synuclein interactomes in the MSA brain and compare them with other common synucleinopathies.