Cytokine concentrations in lung homogenates and plasma of WT and TM^pro/pro mice during murine melioidosis.

Pulmonary and plasma cytokine levels after intranasal infection with 750 CFU of B. pseudomallei. Mice were sacrificed 24, 48 or 72 h after infection. Data are expressed as median (interquartile ranges) of n = 8 mice per group per time point. BD below detection limits, IFN-γ interferon-γ, IL interleukin, MCP-1 monocyte-chemoattractant protein-1, TNF-α tumor necrosis factor-α. *P<0.05, **P<0.01 and ***P<0.001 for WT versus TMpro/pro mice (Mann-Whitney U test).