The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit p

PubMed Central2001-01-30 更新50

Identification of critical residues in loop E in the 5-HT(3AS)R binding site

激素受体结合位点分析

定点突变功能验证

BACKGROUND: The serotonin type 3 receptor (5-HT(3)R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably sign

PubMed Central2002-06-13 更新30

Low-volume jet injection for intradermal immunization in rabbits

基因递送技术

皮内免疫应答

BACKGROUND: This study tested a low-volume (20–30 μl/20–30 μg DNA) jet injection method for intradermal delivery of a DNA vaccine. Jet injection offers the advantages of a needle-less system, low-cost

PubMed Central2002-05-23 更新50

What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis

ANCA相关性血管炎

T细胞免疫致病机制

The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cyto

PubMed Central2000-06-12 更新40