Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand Descriptor: 1-({[(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)sulfonyl]amino}methyl)cyclopentanecarboxylic acid, Bromodomain-containing protein 4 Authors: Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. Deposit date: 2015-07-20 Release date: 2016-01-13 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016人BRD4首个溴结构域（bromodomain）与苯并[cd]吲哚-2(1H)-酮配体复合物的晶体结构 描述符：1-({[(1-乙基-2-氧代-1,2-二氢苯并[cd]吲哚-6-基)磺酰基]氨基}甲基)环戊烷羧酸、含溴结构域蛋白4（Bromodomain-containing protein 4） 作者：Zhang, Y、Song, M、Liu, Z、Xue, X、Xu, Y. 存档日期：2015-07-20 发布日期：2016-01-13 最后修改日期：2024-03-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.62埃（Å） 引用：《苯并[cd]吲哚-2(1H)-酮类强效特异性BET溴结构域抑制剂的发现：基于结构的虚拟筛选、优化及生物学评价》，J.Med.Chem., 59, 2016