The goal of this study is to understand the transcriptional features of CD4+ memory T cells induced by CMV seropositivity and explore their TCR repertoire clonality. Overall design: We selected CMV-as

NIAID Data Ecosystem50

Immune-aging is linked to clinical malignancy and vaccine responses in myeloma. Immune-aging is linked to clinical malignancy and vaccine responses in myeloma

癌细胞衰老

单细胞免疫组学

Several single-cell transcriptomic approaches have been applied to study immune system in MM, and previously implied “T-cell exhaustion” largely based on comparison with signatures derived in murine c

NIAID Data Ecosystem40

Replicative history marks transcriptional and functional disparity in the memory T cell pool

T细胞记忆

单细胞免疫组学

Mice received DivisionRecorder+ or unmodified OT-I T cells and were challenged with LM-OVA. During memory phase we FACS sorted memory CD8+ OT-I T cells (and sub-sorted RFP+ and RFP- cells in the case

NIAID Data Ecosystem70

Targeting CD38 with Daratumumab in refractory Systemic Lupus Erythematosus

单细胞免疫组学

系统性红斑狼疮

Single cell transcriptome and TCR sequencing of FACS-sorted memory T cells in one patient under treatment with the anti CD38-antibody Daratumumab. The patient received Daratumumab at days 0, 7, 14 and

NIAID Data Ecosystem50

Single cell RNA-seq of human CD8+ T cells binding the IAV HLA-A24/PB1 498-505 tetramer

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