CARs-DB

Given the relevance of CARs for both IDPs function and malfunction, we developed CARs-DB, a database containing precomputed predictions for all CARs present in the IDPs deposited in the DisProt database. This web tool allows for the fast and comprehensive exploration of previously unnoticed amyloidogenic regions embedded within IDRs sequences and might turn helpful in identifying disordered interacting regions. It contains >8,900 unique CARs identified in a total of 1711 IDRs. CARs-DB is freely available for users and can be accessed at http://carsdb.ppmclab.com.鉴于CARs在内在无序蛋白（Intrinsically Disordered Proteins, IDPs）的正常功能发挥与异常调控过程中均具有关键作用，我们构建了CARs-DB数据库。该库收录了DisProt数据库中收录的所有IDPs所含CARs的预计算预测结果。本Web工具可实现对嵌入于内在无序区域（Intrinsically Disordered Regions, IDRs）序列中此前未被发现的淀粉样蛋白生成区域（amyloidogenic regions）的快速、全面探索，或可助力无序相互作用区域的识别工作。该库共在1711个IDRs中鉴定得到8900余个独特的CARs。CARs-DB面向所有用户免费开放，访问地址为http://carsdb.ppmclab.com。

搜集汇总

背景与挑战

背景概述

CARs-DB是一个专注于无序蛋白中隐蔽淀粉样区域（CARs）预测的数据库，包含超过8,900个唯一CARs，涉及1,711个无序区域。该数据库免费提供，旨在帮助用户快速探索和识别无序蛋白中的淀粉样区域，可通过指定网址访问。