Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound

Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound Descriptor: 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL, Thyroid hormone receptor beta-1 Authors: Hangeland, J.J, Dejneka, T, Friends, T.J, Devasthale, P, Mellstrom, K, Sandberg, J, Grynfarb, M, Doweyko, A.M, Sack, J.S, Einspahr, H, Farnegardh, M, Husman, B, Ljunggren, J, Koehler, K, Sheppard, C, Malm, J, Ryono, D.E. Deposit date: 2003-10-15 Release date: 2005-02-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3 Å) Cite: Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta. Bioorg.Med.Chem.Lett., 14, 2004与β选择性化合物结合的甲状腺激素受体β（Thyroid hormone receptor beta）配体结合域的晶体结构。描述符：2-[3,5-二溴-4-(4-羟基-3-{羟基[(2-苯乙基)氨基]甲基}苯氧基)苯基]乙烷-1,1-二醇，甲状腺激素受体β-1（Thyroid hormone receptor beta-1）。作者：Hangeland, J.J.、Dejneka, T.、Friends, T.J.、Devasthale, P.、Mellstrom, K.、Sandberg, J.、Grynfarb, M.、Doweyko, A.M.、Sack, J.S.、Einspahr, H.、Farnegardh, M.、Husman, B.、Ljunggren, J.、Koehler, K.、Sheppard, C.、Malm, J.、Ryono, D.E.。沉积日期：2003-10-15；发布日期：2005-02-15；最后修改日期：2024-02-14。实验方法：X射线衍射（分辨率3 Å）。引用文献：甲状腺受体配体 第2部分：对甲状腺激素受体β选择性更优的甲状腺模拟物。《Bioorg.Med.Chem.Lett.》，14卷，2004年。