Primary mid-trimester and term human cytotrophoblast, untreated [RNA-Seq]

We detected a genome-wide differential gene enrichment between mid-trimester and term human placenta. Pathway analysis identified that cytokine-cytokine receptor interaction, NF-?B, and TNF are the leading pathways enriched in term placenta. Our analysis has provided the first-time characterization of the key players of human placental origin with molecular changes across pregnancy, which could drive human labor. Overall design: Total RNAs were extracted from 4 individual placentas at either mid-trimester or term pregnancy with use of Trizol method.