Skeletal and limb anomalies as a result of mutation in hnrnpul1 in zebrafish

Mutations in RNA binding proteins can lead to pleiotropic phenotypes including craniofacial, skeletal, limb and neurological symptoms. Here, we show a developmental role for hnrnpul1 in the zebrafish limb, craniofacial development and in adult onset scoliosis. Furthermore, we demonstrate for the first time a role of hrnpul1 in alternative splicing regulation. Overall design: 3 wild type bio reps, 3 double homozygous hnrnpul1/1l mutant bio reps